Kruppel-like Factor 14 as Driver of Regulatory T-Cell Activity in Intestinal Inflammation
نویسندگان
چکیده
منابع مشابه
Kruppel-like Factor 14 as Driver of Regulatory T-Cell Activity in Intestinal Inflammation
egulatory T cells (Treg cells) have been previously Rfound to play a major role in controlling chronic intestinal inflammation. In the murine model of colitis induced by adoptive transfer of CD4þCD45RBhigh T cells, Treg cells produce anti-inflammatory cytokines such as interleukin-10 and transforming growth factor-b and can suppress intestinal inflammation by inhibiting effector T-cell activity...
متن کاملA Novel Role for Kruppel-like Factor 14 (KLF14) in T-Regulatory Cell Differentiation
BACKGROUND AND AIMS KLF proteins function as epigenetic reprogramming factors during cell differentiation in many cell populations and in engineered iPS cells. In this study, we determined KLF14 function in the regulation of FOXP3, a transcription factor critical for Treg cell differentiation. METHODS We studied the effects of KLF14 on FOXP3 expression at the level of the protein and mRNA. We...
متن کاملKLF 5 ( Kruppel - like factor 5 ( intestinal ) )
KLF5 is a transcription factor. Many KLF5 target genes, such as PDGFa, PPARg, NFkB, cyclinD1, KLF4, and TCR, have been identified in different cell models. KLF5 regulates cell proliferation, cell cycle, apoptosis, and differentiation. KLF5 is an important transcription factor for cardiovascular remodeling and tumor angiogenesis. KLF5 is essential for mouse embryo development. Additionally, KLF5...
متن کاملKruppel-like factor 15 is critical for vascular inflammation.
Activation of cells intrinsic to the vessel wall is central to the initiation and progression of vascular inflammation. As the dominant cellular constituent of the vessel wall, vascular smooth muscle cells (VSMCs) and their functions are critical determinants of vascular disease. While factors that regulate VSMC proliferation and migration have been identified, the endogenous regulators of VSMC...
متن کاملSuberanilohydroxamic Acid as a Pharmacological Kruppel‐Like Factor 2 Activator That Represses Vascular Inflammation and Atherosclerosis
BACKGROUND Kruppel-like factor 2 (KLF2) is an important zinc-finger transcription factor that maintains endothelial homeostasis by its anti-inflammatory, -thrombotic, -oxidative, and -proliferative effects in endothelial cells. In light of the potent vasoprotective effects of KLF2, modulating KLF2 expression or function could give rise to new therapeutic strategies to treat cardiovascular disea...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cellular and Molecular Gastroenterology and Hepatology
سال: 2015
ISSN: 2352-345X
DOI: 10.1016/j.jcmgh.2015.01.003